Hameed Meera, Clarke Kevin, Amer Hoda Zeinab, Mahmet Kathleen, Aisner Seena
Department of Pathology, University of Medicine and Dentistry of New Jersey--New Jersey Medical School, 150 Bergen Street, UHE-141, Newark, NJ 07103, USA.
Cancer Genet Cytogenet. 2007 Sep;177(2):131-4. doi: 10.1016/j.cancergencyto.2007.05.016.
Cellular angiofibroma is a benign mesenchymal neoplasm of female and male genital tract composed of prominent vasculature and stromal spindle cells, often with admixture of adipose tissue. The tumor has histomorphologic similarities to angiomyofibroblastoma and spindle cell lipoma. Herein we describe a tumor arising in the perineal region of a 60-year-old man with morphological and immunohistochemical features of cellular angiofibroma and showing cytogenetic characteristics similar to spindle cell lipoma. To our knowledge, this is the first report of cytogenetic changes in cellular angiofibroma. The genetic overlap of these entities supports their origin from the same mesenchymal stem cell.
细胞性血管纤维瘤是一种发生于男女生殖道的良性间叶性肿瘤，由显著的脉管系统和间质梭形细胞组成，常伴有脂肪组织混合。该肿瘤在组织形态学上与血管肌纤维母细胞瘤和梭形细胞脂肪瘤相似。在此，我们描述了一例发生于一名60岁男性会阴区的肿瘤，具有细胞性血管纤维瘤的形态学和免疫组化特征，并显示出与梭形细胞脂肪瘤相似的细胞遗传学特征。据我们所知，这是细胞性血管纤维瘤细胞遗传学改变的首例报告。这些实体的基因重叠支持它们起源于相同的间充质干细胞。
