Sander Bjoern, Middel Peter, Gunawan Bastian, Schulten Hans-Jürgen, Baum Friedeman, Golas Mariola Monika, Schulze Frank, Grabbe Eckhardt, Parwaresch Reza, Füzesi László
Department of Pathology, University of Göttingen, 37099 Göttingen, Germany.
Hum Pathol. 2007 Apr;38(4):668-72. doi: 10.1016/j.humpath.2006.08.030.
Diagnosis of primary spindle cell tumors of the spleen is challenging because of the limited immunologic and cytogenetic characterization of this rare entity. We report a case of primary follicular dendritic cell (FDC) sarcoma of the spleen in a 44-year-old woman. Indications for FDC included positive staining for CD21, Ki-M4P, CD14, and fascin. Expression of both standard FDC markers CD23 and CD35 was detected immunohistochemically using tyramide signal amplification. Cytogenetic analysis revealed multiple clonal chromosomal aberrations involving unbalanced translocations of chromosomes X, 3, 5, 7, 8, 9, and 10, leading to net gains at 3q, 7p, 8q, and 9q and net losses at Xp, 8p, 9p, and 10p. Loss at Xp has been described previously in another tumor with FDC features, suggesting that this aberration might play a common role in this malignancy.
脾脏原发性梭形细胞瘤的诊断具有挑战性，因为这种罕见实体的免疫和细胞遗传学特征有限。我们报告了一例44岁女性脾脏原发性滤泡树突状细胞（FDC）肉瘤的病例。FDC的指标包括CD21、Ki-M4P、CD14和fascin染色阳性。使用酪胺信号放大免疫组化检测到标准FDC标志物CD23和CD35的表达。细胞遗传学分析显示多个克隆性染色体畸变，涉及X、3、5、7、8、9和10号染色体的不平衡易位，导致3q、7p、8q和9q的净增益以及Xp、8p、9p和10p的净损失。Xp缺失先前在另一例具有FDC特征的肿瘤中已有描述，表明这种畸变可能在这种恶性肿瘤中起共同作用。
