Ihedioha J I, Ochiogu I S, Ihedioha T E
Departments of Veterinary Pathology and Microbiology, University of Nigeria Nsukka, PO Box 3236, Nsukka 410001, Nigeria.
J Comp Pathol. 2007 Feb-Apr;136(2-3):206-11. doi: 10.1016/j.jcpa.2007.01.003. Epub 2007 Mar 26.
This study investigated the effects of co-administration of Na-EDTA and diminazene aceturate (DA) on the level of parasitaemia (LOP), parasite clearance, packed cell volume (PCV) and post-infection survival time (PIST) in mice infected with DA-resistant Trypanosoma brucei. Five groups of 10 mice were treated as follows: infected and treated with Na-EDTA+DA; infected and treated with DA alone; infected and treated with Na-EDTA alone; infected-untreated; and uninfected-untreated. The co-administration of Na-EDTA and DA led to reduced LOP and improvements in PCV (P<0.05), as compared with treatment with DA alone. Mice treated with Na-EDTA+DA had a marginally (P>0.05) higher PIST than did mice treated with DA alone. Comparison of the group given Na-EDTA alone with the infected-untreated group showed that the former group had a significantly lower (P<0.01) LOP, improved PCV (P<0.05) and higher (P<0.01) PIST. It was concluded that the co-administration of Na-EDTA and DA led to a slight potentiation of DA in the treatment of mice infected with DA-resistant T. brucei, and that the administration of Na-EDTA alone significantly enhanced the resistance of the infected mice.
本研究调查了联合给予乙二胺四乙酸钠（Na-EDTA）和乙酰氨基阿维菌素（DA）对感染耐DA布氏锥虫小鼠的寄生虫血症水平（LOP）、寄生虫清除率、红细胞压积（PCV）和感染后存活时间（PIST）的影响。将五组每组10只小鼠进行如下处理：感染并给予Na-EDTA+DA治疗；感染并单独给予DA治疗；感染并单独给予Na-EDTA治疗；感染但未治疗；未感染且未治疗。与单独给予DA治疗相比，联合给予Na-EDTA和DA可降低LOP并改善PCV（P<0.05）。接受Na-EDTA+DA治疗的小鼠的PIST略高于单独接受DA治疗的小鼠（P>0.05）。将单独给予Na-EDTA的组与感染但未治疗的组进行比较，结果显示前一组的LOP显著更低（P<0.01），PCV有所改善（P<0.05），PIST更高（P<0.01）。得出的结论是，联合给予Na-EDTA和DA在治疗感染耐DA布氏锥虫的小鼠时可使DA有轻微增效作用，且单独给予Na-EDTA可显著增强感染小鼠的抵抗力。
