Gudmundsson Kristjan S, Johns Brian A
Department of Medicinal Chemistry, Infectious Diseases Center of Excellence for Drug Discovery, GlaxoSmithKline Research & Development, Five Moore Drive, Research Triangle Park, NC 27709-3398, USA.
Bioorg Med Chem Lett. 2007 May 15;17(10):2735-9. doi: 10.1016/j.bmcl.2007.02.079. Epub 2007 Mar 3.
Synthesis of a series of 2-aryl-3-pyrimidyl-imidazo[1,2-a]pyridines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the 2-aryl, 3-heteroaryl as well as other imidazopyridine substituents are outlined and resulting effects on antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar or better than acyclovir are described.
描述了一系列对单纯疱疹病毒具有强效活性的2-芳基-3-嘧啶基-咪唑并[1,2-a]吡啶的合成。概述了允许2-芳基、3-杂芳基以及其他咪唑并吡啶取代基发生变化的合成方法，并强调了其对抗病毒活性的影响。描述了几种体外抗病毒活性与阿昔洛韦相似或更好的化合物。
