Palacios Isabel M
Department of Zoology, University of Cambridge, Downing Street CB2 3EJ, United Kingdom.
Semin Cell Dev Biol. 2007 Apr;18(2):163-70. doi: 10.1016/j.semcdb.2007.01.008. Epub 2007 Jan 26.
The localisation of transcripts to specific regions of the cell probably occurs in all cell types and has many distinct functions that go from the control of body axis formation to learning and memory. mRNAs can be localised by a variety of mechanisms including local protection from degradation, diffusion to a localised anchor, and active transport by motor proteins along the cytoskeleton. In this review, I consider the evidence for each of these mechanisms using a limited, but illustrative, number of examples of localised mRNAs.
转录本在细胞特定区域的定位可能发生在所有细胞类型中,并且具有许多不同的功能,从身体轴形成的控制到学习和记忆。信使核糖核酸(mRNA)可以通过多种机制进行定位,包括局部保护以免于降解、扩散到局部锚定物以及由驱动蛋白沿着细胞骨架进行主动运输。在这篇综述中,我使用数量有限但具有说明性的定位mRNA的例子来考量这些机制各自的证据。