Kahn-Greene Ellen T, Killgore Desiree B, Kamimori Gary H, Balkin Thomas J, Killgore William D S
Department of Behavioral Biology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research (WRAIR), 503 Robert Grant Avenue, Silver Spring, MD 20910, USA.
Sleep Med. 2007 Apr;8(3):215-21. doi: 10.1016/j.sleep.2006.08.007. Epub 2007 Mar 26.
Sleep loss leads to temporary changes in mood and cognition, and is associated with reduced cerebral metabolism within the prefrontal cortex, similar to findings observed in some psychiatric disorders. However, the extent to which sleep deprivation may be associated with the emergence of clinical symptoms of psychopathology in healthy normal individuals is not clear.
The Personality Assessment Inventory (PAI) was administered to 25 healthy adults at rested baseline and again after 56h of continuous wakefulness.
Comparisons showed a significant global increase in PAI psychopathology scores from baseline to sleep-deprived sessions, particularly for somatic complaints, anxiety, depression, and paranoia. Mean elevations for the clinical scales remained within normal limits, however. In contrast, sleep loss was not associated with significant changes in anxiety-related disorders, manic symptoms, borderline, schizophrenic, or antisocial features.
Two nights without sleep may lead to a sub-clinical increase in self-reported affective symptoms of psychopathology while having little effect on symptoms of thought disorder, psychotic processes, or behavioral dysregulation. These data suggest that sleep loss may be differentially disruptive to regions of the brain involved in affective regulation and may, therefore, serve as a model for understanding the brain dysfunction associated with affective psychopathology.
睡眠不足会导致情绪和认知的暂时变化，并与前额叶皮质内的脑代谢降低有关，这与在一些精神疾病中观察到的结果相似。然而，睡眠剥夺在健康正常个体中与精神病理学临床症状出现的关联程度尚不清楚。
对25名健康成年人在休息基线时及连续清醒56小时后进行了人格评估量表（PAI）测试。
比较显示，从基线到睡眠剥夺阶段，PAI精神病理学评分总体显著增加，尤其是在躯体不适、焦虑、抑郁和偏执方面。然而，临床量表的平均升高仍在正常范围内。相比之下，睡眠不足与焦虑相关障碍、躁狂症状、边缘性、精神分裂症或反社会特征的显著变化无关。
两晚不睡觉可能会导致自我报告的精神病理学情感症状出现亚临床增加，而对思维障碍、精神病性过程或行为失调症状影响很小。这些数据表明，睡眠不足可能对参与情感调节的脑区有不同程度的干扰，因此可能作为理解与情感精神病理学相关的脑功能障碍的模型。
