Bedkowska Grazyna Ewa, Lawicki Sławomir, Szmitkowski Maciej
Zakład Diagnostyki Biochemicznej Akademii Medycznej w Białymstoku, Białystok, Poland.
Postepy Hig Med Dosw (Online). 2007;61:122-8.
Tumor markers play an important role in the diagnosis of cancer. Cervical carcinoma and endometrial cancer are the most frequent diseases of the reproductive organs and their morbidity rates are constantly increasing. Many tumor markers may be used in the diagnosis and monitoring of endometrial and cervical carcinoma, for example CA 125, SCC-Ag, TPA, TPS, and CYFRA 21-1. New tumor markers useful in the early diagnosis and in monitoring the treatment and recurrence of the uterine cancer are still being sought. Investigations are underway on such substances as cytokines (e.g. M-CSF) and molecular markers of carcinogenesis (e.g. K-ras and p53).
肿瘤标志物在癌症诊断中发挥着重要作用。宫颈癌和子宫内膜癌是生殖器官最常见的疾病,其发病率在不断上升。许多肿瘤标志物可用于子宫内膜癌和宫颈癌的诊断及监测,例如CA 125、鳞状细胞癌抗原(SCC-Ag)、组织多肽抗原(TPA)、组织多肽特异性抗原(TPS)和细胞角蛋白19片段(CYFRA 21-1)。人们仍在寻找可用于子宫癌早期诊断以及监测治疗和复发情况的新型肿瘤标志物。目前正在对细胞因子(如巨噬细胞集落刺激因子,M-CSF)和致癌作用的分子标志物(如K-ras和p53)等物质进行研究。