米替福新和两种新型抗真菌双阳离子盐对一组77种皮肤癣菌的体外活性。
In vitro activities of miltefosine and two novel antifungal biscationic salts against a panel of 77 dermatophytes.
作者信息
Tong Zhongsheng, Widmer Fred, Sorrell Tania C, Guse Zofia, Jolliffe Katrina A, Halliday Catriona, Lee Ok Cha, Kong Fanrong, Wright Lesley C, Chen Sharon C A
机构信息
Centre for Infectious Diseases and Microbiology Laboratory, Westmead Hospital, Westmead, New South Wales 2145, Australia.
出版信息
Antimicrob Agents Chemother. 2007 Jun;51(6):2219-22. doi: 10.1128/AAC.01382-06. Epub 2007 Mar 19.
Abstract
The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecane (PYR), 1,12-bis(tributylammonium)dodecane (AM), itraconazole (ITC), terbinafine (TRB), and butenafine (BTF) were compared. Geometric mean MICs of TRB, BTF, ITC, MI, PYR, and AM were 0.039, 0.059, 1.718, 0.671, 6.006, and 4.771 microg/ml, respectively. MI was more active than ITC (P < 0.001).
摘要
比较了77种皮肤癣菌对米替福新（MI）、1,12-双（4-戊基吡啶鎓）十二烷（PYR）、1,12-双（三丁基铵）十二烷（AM）、伊曲康唑（ITC）、特比萘芬（TRB）和布替萘芬（BTF）的敏感性。TRB、BTF、ITC、MI、PYR和AM的几何平均MIC分别为0.039、0.059、1.718、0.671、6.006和4.771微克/毫升。MI比ITC更具活性（P<0.001）。
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