Tandan R, Lewis G A, Badger G B, Fries T J
Department of Neurology, University of Vermont College of Medicine, Burlington.
Diabetes Care. 1992 Jan;15(1):15-8. doi: 10.2337/diacare.15.1.15.
To examine the effect of capsaicin on sensory function in painful diabetic neuropathy.
We examined the effects of topical 0.075% capsaicin cream on thermal and vibration thresholds in 22 subjects with painful diabetic neuropathy who participated in a double-blind vehicle-controlled therapeutic trial.
After 8 wk of use, there was no significant change in warm and vibration thresholds, but the cold threshold was significantly reduced by capsaicin and vehicle creams to an equal degree. In fewer subjects who used capsaicin cream in an open-label study, there was no significant effect on sensory thresholds after up to 32 wk of use.
Although our results and those of others show no adverse effects of topical 0.075% capsaicin on human sensory function, even in subjects with preexisting neuropathic sensory impairment, the small number of subjects tested does not justify an inferential statement on safety. Further studies in more subjects are warranted to ensure the long-term safety of capsaicin for pain relief in humans.
研究辣椒素对疼痛性糖尿病神经病变感觉功能的影响。
我们在22名患有疼痛性糖尿病神经病变的受试者中进行了一项双盲赋形剂对照治疗试验，研究外用0.075%辣椒素乳膏对热阈值和振动阈值的影响。
使用8周后，温觉阈值和振动阈值无显著变化，但辣椒素乳膏和赋形剂乳膏均使冷觉阈值显著降低，且降低程度相同。在一项开放标签研究中使用辣椒素乳膏的较少受试者中，使用长达32周后对感觉阈值无显著影响。
尽管我们的研究结果以及其他研究结果表明，外用0.075%辣椒素对人体感觉功能无不良影响，即使是在已有神经病变性感觉障碍的受试者中也是如此，但受试人数较少，不足以就安全性做出推断性陈述。有必要对更多受试者进行进一步研究，以确保辣椒素用于缓解人类疼痛的长期安全性。
