Scheffler N M, Sheitel P L, Lipton M N
American Center for Foot Health Research, Baltimore, MD 21227.
J Am Podiatr Med Assoc. 1991 Jun;81(6):288-93. doi: 10.7547/87507315-81-6-288.
An 8-week, double-blind, vehicle-controlled study was conducted to determine the effectiveness of topical capsaicin 0.075% cream in relieving pain associated with diabetic neuropathy. Patients were selected who experienced moderate to very severe pain, which interfered with sleep or activities on a daily basis, and who were unresponsive or intolerant to conventional therapy. The results after 8 weeks showed a statistically significant difference in favor of the capsaicin-treated patients, with 90% of these patients improved. The results of this study indicate that topical capsaicin 0.075% cream is safe and effective in managing painful diabetic neuropathy.
进行了一项为期8周的双盲、赋形剂对照研究，以确定0.075%辣椒素乳膏局部用药缓解糖尿病性神经病变相关疼痛的有效性。入选患者为经历中度至非常严重疼痛（该疼痛每日干扰睡眠或日常活动）且对传统治疗无反应或不耐受的患者。8周后的结果显示，辣椒素治疗组患者有统计学显著差异，其中90%的患者病情改善。该研究结果表明局部使用0.075%辣椒素乳膏治疗糖尿病性神经病变疼痛安全有效。
