Majeroni Barbara A, Patel Parag
Dept. of Family Medicine, State University of New York at Buffalo, Buffalo, New York 14215, USA.
Am Fam Physician. 2007 Mar 1;75(5):667-70.
The combination of autoimmune adrenal insufficiency with autoimmune thyroid disease and/or type 1 autoimmune diabetes mellitus defines autoimmune polyglandular syndrome, type II. The conditions may occur in any order, and diagnosis is confounded by the nonspecific nature of the symptoms of adrenal insufficiency and hypothyroidism. The disorder is not common, but consequences can be life threatening when the diagnosis is overlooked. The conditions usually present in midlife, and women are affected more often than men. The cosyntropin test is recommended for diagnosing adrenal insufficiency, which must be present to diagnose this syndrome. Hormone therapy for each condition is similar to treatment that would be provided if the conditions occurred separately, except that treatment for adrenal insufficiency must be given before thyroid therapy is started when the conditions occur together.
自身免疫性肾上腺功能不全与自身免疫性甲状腺疾病和/或1型自身免疫性糖尿病并存，定义为Ⅱ型自身免疫性多腺体综合征。这些病症可能以任何顺序出现，肾上腺功能不全和甲状腺功能减退症状的非特异性使诊断变得复杂。这种疾病并不常见，但如果漏诊，后果可能危及生命。这些病症通常在中年出现，女性比男性更易受影响。建议采用促肾上腺皮质激素试验来诊断肾上腺功能不全，诊断该综合征必须存在肾上腺功能不全。每种病症的激素治疗与单独出现这些病症时所提供的治疗相似，只是当两种病症同时出现时，肾上腺功能不全的治疗必须在开始甲状腺治疗之前进行。
