Giddi Hema Sagar, Arunagirinathan M A, Bellare Jayesh R
Department of Chemical Engineering, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India.
Indian J Exp Biol. 2007 Feb;45(2):133-59.
Role of self assembled structures as a vehicle is significant over the years. Their applications have been found for all routes of drug delivery. These micro and nano structures are containers loaded with drugs, ideal for targeted and sustained release of the drug. Drug efficacy depends on the drug loaded into the vehicle, temperature, drug solubility, pH, release characteristics, additives and most significantly, the vehicle morphology. This in turn suggests that the same vehicle cannot be used with high efficiency for all types of drugs and locations where the drug delivery has to take place. The status of various self assembled structures and their applications in drug delivery is reviewed in this communication.
多年来，自组装结构作为一种载体的作用十分显著。已发现它们在所有药物递送途径中均有应用。这些微米和纳米结构是装载药物的容器，非常适合药物的靶向和持续释放。药物疗效取决于装载在载体中的药物、温度、药物溶解度、pH值、释放特性、添加剂，最重要的是载体形态。这反过来表明，同一载体不能高效地用于所有类型的药物以及需要进行药物递送的部位。本文对各种自组装结构及其在药物递送中的应用现状进行了综述。
