Post Graduate Department of Biotechnology, Utkal University, Vani Vihar, Bhubaneswar, Odisha, India.
Departmentof Life Science, National Institute of Technology, Rourkela, Odisha, India.
Nanomedicine. 2019 Jun;18:196-220. doi: 10.1016/j.nano.2019.03.004. Epub 2019 Mar 21.
Emergence of new virus and their heterogeneity are growing at an alarming rate. Sudden outburst of Nipah virus (NiV) has raised serious question about their instant management using conventional medication and diagnostic measures. A coherent strategy with versatility and comprehensive perspective to confront the rising distress could perhaps be effectuated by implementation of nanotechnology. But in concurrent to resourceful and precise execution of nano-based medication, there is an ultimate need of concrete understanding of the NIV pathogenesis. Moreover, to amplify the effectiveness of nano-based approach in a conquest against NiV, a list of developed nanosystem with antiviral activity is also a prerequisite. Therefore the present review provides a meticulous cognizance of cellular and molecular pathogenesis of NiV. Conventional as well several nano-based diagnosis experimentations against viruses have been discussed. Lastly, potential efficacy of different forms of nano-based systems as convenient means to shield mankind against NiV has also been introduced.
新病毒的出现及其异质性正以惊人的速度增长。尼帕病毒（NiV）的突然爆发，对其使用传统药物和诊断措施进行即时管理提出了严峻的质疑。为了应对不断增加的困境，采用纳米技术可能会实施一种具有通用性和全面性视角的协调战略。但是，在实施基于纳米的药物时，需要有资源和精确的执行能力，同时还需要对 NIV 发病机制有具体的了解。此外，为了提高基于纳米的方法在对抗 NiV 中的效果，还需要列出具有抗病毒活性的已开发纳米系统。因此，本综述提供了对 NiV 的细胞和分子发病机制的详细认识。讨论了针对病毒的常规和几种基于纳米的诊断实验。最后，还介绍了不同形式的基于纳米的系统作为保护人类免受 NiV 侵害的便捷手段的潜在功效。
