Yonsei University, Translational Research Center for Protein Function Control, Department of Materials Science and Engineering, Seoul, Korea.
Expert Opin Drug Deliv. 2010 Mar;7(3):341-51. doi: 10.1517/17425240903559841.
Among many nanostructural shapes, filamentous shapes can have unique advantages over the others, including longer persistence in the bloodstream. With the advent of nanotechnology in recent years, a variety of shape-controlled nanostructures has been fabricated. As a wide variety of building blocks can self-assemble into filamentous nanostructures, there are many options available for biomaterial developments with filamentous nanostructures. Similarly to conventional spherical micelles, most filamentous nanostructures have hydrophobic cores where hydrophobic guest molecules can be encapsulated, which enable them to be used in drug delivery applications. Moreover, on suitable molecular design and self-assembly process control, filamentous nanostructures can also be made to deliver nucleic acids or even both drugs and nucleic acids simultaneously.
This review describes the self-assembly process, current developments, and prospects of filamentous nanostructures in drug and gene delivery applications.
This review should be helpful in gaining insight into the self-assembly process and nanostructural shape control, the advantages of constructing filamentous nanostructures, and the design of more advanced nanobiomaterials.
At present, the development of multifunctional nanostructures is one of the main focuses in nanobiomaterial developments. In this regard, filamentous nanostructures can be good initial targets for tailor-made nanostructure developments because they have more structural variables, as compared with spherical micelles.
在许多纳米结构形状中，丝状形状相对于其他形状具有独特的优势，包括在血液中更长的持久性。近年来，随着纳米技术的出现，已经制造出了各种形状可控的纳米结构。由于各种各样的构建块可以自组装成丝状纳米结构，因此有许多选择可用于具有丝状纳米结构的生物材料开发。与传统的球形胶束类似，大多数丝状纳米结构都有疏水性核心，可以封装疏水性客体分子，这使它们能够用于药物输送应用。此外，通过合适的分子设计和自组装过程控制，也可以使丝状纳米结构同时输送核酸甚至药物和核酸。
这篇综述描述了丝状纳米结构在药物和基因传递应用中的自组装过程、当前的发展和前景。
读者应该可以深入了解自组装过程和纳米结构形状控制、构建丝状纳米结构的优势以及更先进的纳米生物材料的设计。
目前，多功能纳米结构的发展是纳米生物材料发展的主要关注点之一。在这方面，与球形胶束相比，丝状纳米结构具有更多的结构变量，因此可以作为定制纳米结构开发的良好初始目标。
