Patel A R, Vavia P R
Pharmaceutical Division, Mumbai University Institute of Chemical Technology, Matunga, Mumbai 400019, India.
Indian J Exp Biol. 2007 Feb;45(2):166-74.
Pharmaceutical inhalation aerosols have been playing a crucial role in the health and well being of millions of people throughout the world for many years. The technology's continual advancement, the ease of use and the more desirable pulmonary-rather-than-needle delivery for systemic drugs has increased the attraction for the pharmaceutical aerosol in recent years. But administration of drugs by the pulmonary route is technically challenging because oral deposition can be high, and variations in inhalation technique can affect the quantity of drug delivered to the lungs. Recent advances in nanotechnology, particularly drug delivery field have encouraged formulation scientists to expand their reach in solving tricky problems related to drug delivery. Moreover, application of nanotechnology to aerosol science has opened up a new category of pharmaceutical aerosols (collectively known as nanoenabled-aerosols) with added advantages and effectiveness. In this review, some of the latest approaches of nano-enabled aerosol drug delivery system (including nano-suspension, trojan particles, bioadhesive nanoparticles and smart particle aerosols) that can be employed successfully to overcome problems of conventional aerosol systems have been introduced.
多年来，药物吸入气雾剂在全世界数百万人的健康和福祉方面发挥着至关重要的作用。近年来，随着该技术的不断进步、使用的便利性以及全身用药更理想的肺部给药（而非注射给药）方式，药物气雾剂的吸引力与日俱增。但是，通过肺部途径给药在技术上具有挑战性，因为口腔沉积量可能很高，而且吸入技术的差异会影响输送到肺部的药物量。纳米技术的最新进展，尤其是在药物递送领域的进展，促使制剂科学家扩大其解决与药物递送相关棘手问题的能力范围。此外，纳米技术在气雾剂科学中的应用开创了一类具有额外优势和功效的新型药物气雾剂（统称为纳米增强气雾剂）。在本综述中，介绍了一些纳米增强气雾剂药物递送系统的最新方法（包括纳米混悬液、特洛伊颗粒、生物粘附纳米颗粒和智能颗粒气雾剂），这些方法可以成功用于克服传统气雾剂系统的问题。
