Ladewig Katharina, Xu Zhi Ping, Lu Gao Qing Max
The University of Queensland, ARC Centre of Excellence for Functional Nanomaterials, Australian Institute for Bioengineering and Nanotechnology, St Lucia QLD, Australia.
Expert Opin Drug Deliv. 2009 Sep;6(9):907-22. doi: 10.1517/17425240903130585.
Layered double hydroxides (LDHs) have been known for many decades as catalyst and ceramic precursors, traps for anionic pollutants, catalysts and additives for polymers, but their successful synthesis on the nanometer scale a few years ago opened up a whole new field for their application in nanomedicine. The delivery of drugs and other therapeutic/bioactive molecules (e.g., peptides, proteins, nucleic acids) to mammalian cells is an area of research that is of tremendous importance to medicine and provides manifold applications for any new developments in the area of nanotechnology. Among the many different nanoparticles that have been shown to facilitate gene and/or drug delivery, LDH nanoparticles have attracted particular attention owing to their many desirable properties. This review aims to report recent progress in gene and drug delivery using LDH nanoparticles. It summarizes the advantages and disadvantages of using LDH nanoparticles as carriers for nucleic acids and drugs against the general background of bottlenecks that are encountered by cellular delivery systems. It describes further the models that have been proposed for the internalization of LDH nanoparticles into cells so far and discusses the intracellular fate of the particles and their cargo. The authors offer some remarks on how this field of research will progress in the near future and which challenges need to be overcome before LDH nanoparticles can be used in a clinical setting.
层状双氢氧化物（LDHs）作为催化剂和陶瓷前驱体、阴离子污染物捕获剂、聚合物催化剂及添加剂，已为人所知数十年。但几年前其在纳米尺度上的成功合成，为其在纳米医学中的应用开辟了全新领域。将药物及其他治疗性/生物活性分子（如肽、蛋白质、核酸）递送至哺乳动物细胞，是一个对医学极为重要的研究领域，为纳米技术领域的任何新进展提供了多种应用。在已被证明可促进基因和/或药物递送的众多不同纳米颗粒中，LDH纳米颗粒因其诸多理想特性而备受关注。本综述旨在报道使用LDH纳米颗粒进行基因和药物递送的最新进展。它在细胞递送系统所面临瓶颈的总体背景下，总结了将LDH纳米颗粒用作核酸和药物载体的优缺点。进一步描述了目前已提出的LDH纳米颗粒内化进入细胞的模型，并讨论了颗粒及其所载物在细胞内的命运。作者对该研究领域在不久的将来将如何发展，以及在LDH纳米颗粒可用于临床之前需要克服哪些挑战发表了一些看法。
