Biswas Deb, Marnane Conor N, Mal Ranjit, Baldwin David
Department of Otolaryngology and Head & Neck Surgery, Southmead Hospital, University of Bristol, Westbury on Trym, Bristol BS10 5NB, UK.
Auris Nasus Larynx. 2007 Sep;34(3):353-9. doi: 10.1016/j.anl.2007.01.006. Epub 2007 Mar 21.
To present our experience in managing a large case series of extracranial schwannomas highlighting presenting features, diagnostic difficulties, and outcomes associated with surgical treatment of these tumours.
A retrospective case note study of 31 patients with a diagnosis of extracranial schwannoma seen in the Department of Otolaryngology, Head and Neck Surgery at Southmead Hospital, a tertiary referral centre and University hospital between 1 June 1993 and 30 May 2003.
The commonest anatomical location was in the neck (42%) and an isolated neck lump was the commonest presentation (77%). Pressure symptoms were the next most common mode of presentation, and were often a helpful indicator of the nerve of origin. The nerve of origin was identified in 47% of patients who underwent surgery. Immunohistochemistry was a useful tool in the diagnosis of these tumours and magnetic resonance imaging was the preferred imaging technique to delineate their extent. The most significant postoperative morbidity was associated with the schwannomas of the vagus nerve, sympathetic chain, hypoglossal nerve, glossopharyngeal nerve and the facial nerve.
Schwannomas can present in a wide variety of sites within the head and neck region and therefore it is important that otolaryngologists and head-neck surgeons are familiar with the more common sites of presentation and the potential difficulties associated with the diagnosis and management of these tumours. Adequate imaging should be carried out preoperatively to gain as much information as possible about the individual tumour and allow informed patient counseling regarding to potential risks and morbidity of surgical intervention.
介绍我们在处理大量颅外神经鞘瘤病例系列中的经验,重点阐述这些肿瘤的临床表现、诊断难点以及手术治疗的结果。
对1993年6月1日至2003年5月31日期间在南米德医院耳鼻喉科、头颈外科就诊的31例诊断为颅外神经鞘瘤的患者进行回顾性病例记录研究。该医院是一家三级转诊中心和大学医院。
最常见的解剖位置在颈部(42%),孤立的颈部肿块是最常见的表现(77%)。压迫症状是其次最常见的表现方式,且常常是起源神经的一个有用指示。在接受手术的患者中,47%的患者确定了起源神经。免疫组织化学是诊断这些肿瘤的一种有用工具,磁共振成像(MRI)是描绘其范围的首选成像技术。最显著的术后并发症与迷走神经、交感神经链、舌下神经、舌咽神经和面神经的神经鞘瘤有关。
神经鞘瘤可出现在头颈部区域的多种部位,因此耳鼻喉科医生和头颈外科医生熟悉这些肿瘤更常见的表现部位以及与诊断和管理相关的潜在困难很重要。术前应进行充分的成像检查,以获取关于单个肿瘤的尽可能多的信息,并就手术干预的潜在风险和并发症为患者提供充分的咨询。