Billington Richard A, Bruzzone Santina, De Flora Antonio, Genazzani Armando A, Koch-Nolte Friedrich, Ziegler Mathias, Zocchi Elena
DiSCAFF and the DFB Centre, Università del Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy.
Mol Med. 2006 Nov-Dec;12(11-12):324-7. doi: 10.2119/2006–00075.Billington.
In addition to the well-known metabolic functions of NAD and NADP, it is rapidly emerging that these 2 pyridine nucleotides and their derivatives also play important roles in cell signaling. Surprisingly, a number of NAD(P) metabolizing enzymes and NAD(P) targets have been found on the outer surface of the plasma membrane and the presence of NAD has been confirmed in extracellular fluids. These findings have opened the door to a new field of research aimed at elucidating the contribution of extracellular pyridine nucleotides in physiological signaling pathways and pathological conditions.
除了众所周知的NAD和NADP的代谢功能外，越来越多的证据表明，这两种吡啶核苷酸及其衍生物在细胞信号传导中也发挥着重要作用。令人惊讶的是，在质膜外表面发现了许多NAD(P)代谢酶和NAD(P)靶点，并且在细胞外液中也证实了NAD的存在。这些发现为一个新的研究领域打开了大门，该领域旨在阐明细胞外吡啶核苷酸在生理信号通路和病理状态中的作用。
