Lambert Estelle V, Goedecke Julia H, Bluett Kerry, Heggie Kerry, Claassen Amanda, Rae Dale E, West Sacha, Dugas Jonathan, Dugas Lara, Meltzeri Shelly, Charlton Karen, Mohede Inge
UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, PO Box 115 Newlands, 7725, South Africa.
Br J Nutr. 2007 May;97(5):1001-11. doi: 10.1017/S0007114507172822.
The aim of this study was to measure the effects of 12 weeks of conjugated linoleic acid (CLA) supplementation on body composition, RER, RMR, blood lipid profiles, insulin sensitivity and appetite in exercising, normal-weight persons. In this double-blind, randomised, controlled trial, sixty-two non-obese subjects (twenty-five men, thirty-seven women) received either 3.9 g/d CLA or 3.9 g high-oleic acid sunflower oil for 12 weeks. Prior to and after 12 weeks of supplementation, oral glucose tolerance, blood lipid concentrations, body composition (dual-energy X-ray absorptiometry and computerised tomography scans), RMR, resting and exercising RER and appetite were measured. There were no significant effects of CLA on body composition or distribution, RMR, RER or appetite. During the oral glucose tolerance tests, mean plasma insulin concentrations (0, 30, 120 min) were significantly lower (P= 0.04) in women who supplemented with CLA (24.3 (SD 9.7) to 20.4 (SD 8.5) microU/ml) compared to high-oleic acid sunflower oil control (23.7 (SD 9.8) to 26.0 (SD 8.8) microU/ml). Serum NEFA levels in response to oral glucose were attenuated in both men and women in the CLA (P=0.001) compared to control group. However, serum total cholesterol and LDL-cholesterol concentrations decreased in both groups and HDL-cholesterol concentrations decreased in women over 12 weeks (P=0.001, P=0.02, P=0.02, respectively). In conclusion, mixed-isomer CLA supplementation had a favourable effect on serum insulin and NEFA response to oral glucose in non-obese, regularly exercising women, but there were no CLA-specific effects on body composition, energy expenditure or appetite.
本研究的目的是测量补充12周共轭亚油酸（CLA）对正常体重的运动人群的身体成分、呼吸商（RER）、静息代谢率（RMR）、血脂谱、胰岛素敏感性和食欲的影响。在这项双盲、随机、对照试验中，62名非肥胖受试者（25名男性，37名女性）接受了为期12周的每日3.9克CLA或3.9克高油酸葵花籽油。在补充12周前后，测量了口服葡萄糖耐量、血脂浓度、身体成分（双能X线吸收法和计算机断层扫描）、RMR、静息和运动时的RER以及食欲。CLA对身体成分或分布、RMR、RER或食欲没有显著影响。在口服葡萄糖耐量试验期间，与高油酸葵花籽油对照组（从23.7（标准差9.8）至26.0（标准差8.8）微单位/毫升）相比，补充CLA的女性（从24.3（标准差9.7）至20.4（标准差8.5）微单位/毫升）的平均血浆胰岛素浓度（0、30、120分钟时）显著降低（P = 0.04）。与对照组相比，CLA组的男性和女性口服葡萄糖后血清非酯化脂肪酸（NEFA）水平均有所降低（P = 0.001）。然而，两组的血清总胆固醇和低密度脂蛋白胆固醇浓度均下降，且在12周内女性的高密度脂蛋白胆固醇浓度下降（分别为P = 0.001、P = 0.02、P = 0.02）。总之，补充混合异构体CLA对非肥胖、经常运动的女性口服葡萄糖后的血清胰岛素和NEFA反应有有利影响，但CLA对身体成分、能量消耗或食欲没有特定影响。
