Putera Husna Dharma, Doewes Rumi Iqbal, Shalaby Mohammed Nader, Ramírez-Coronel Andrés Alexis, Clayton Zachary S, Abdelbasset Walid Kamal, Murtazaev Saidmurodkhon S, Jalil Abduladheem Turki, Rahimi Pegah, Nattagh-Eshtivani Elyas, Malekahmadi Mahsa, Pahlavani Naseh
Department of Surgery, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia.
Faculty of Sport, Universitas Sebelas Maret, Jl. Ir. Sutami, 36A, Kentingan, Surakarta, Indonesia.
Nutr Metab (Lond). 2023 Aug 29;20(1):35. doi: 10.1186/s12986-023-00758-9.
Conjugated linoleic acids (CLAs) are polyunsaturated fatty acids primarily found in dairy products and ruminant animal products such as beef, lamb, and butter. Supplementation of CLAs has recently become popular among athletes due to the variety of health-promoting effects, including improvements in physical performance. Preclinical and some clinical studies have shown that CLAs can reduce inflammation and oxidative stress and favorably modulate body composition and physical performance; however, the results of previously published clinical trials are mixed. Here, we performed a comprehensive review of previously published clinical trials that assessed the role of CLAs in modulating inflammation, oxidative stress, body composition, and select indices of physical performance, emphasizing the molecular mechanisms governing these changes. The findings of our review demonstrate that the effect of supplementation with CLAs on inflammation and oxidative stress is controversial, but this supplement can decrease body fat mass and increase physical performance. Future well-designed randomized clinical trials are warranted to determine the effectiveness of (1) specific doses of CLAs; (2) different dosing durations of CLAs; (3) various CLA isomers, and the exact molecular mechanisms by which CLAs positively influence oxidative stress, inflammation, body composition, and physical performance.
共轭亚油酸（CLAs）是主要存在于乳制品和反刍动物产品（如牛肉、羊肉和黄油）中的多不饱和脂肪酸。由于其具有多种促进健康的作用，包括改善身体机能，近年来补充共轭亚油酸在运动员中变得很流行。临床前研究和一些临床研究表明，共轭亚油酸可以减轻炎症和氧化应激，并对身体成分和身体机能产生有益的调节作用；然而，此前发表的临床试验结果并不一致。在此，我们对之前发表的评估共轭亚油酸在调节炎症、氧化应激、身体成分及特定身体机能指标方面作用的临床试验进行了全面综述，重点关注了控制这些变化的分子机制。我们的综述结果表明，补充共轭亚油酸对炎症和氧化应激的影响存在争议，但这种补充剂可以减少体脂量并提高身体机能。未来有必要进行精心设计的随机临床试验，以确定（1）共轭亚油酸的特定剂量；（2）共轭亚油酸的不同给药持续时间；（3）各种共轭亚油酸异构体的有效性，以及共轭亚油酸对氧化应激、炎症、身体成分和身体机能产生积极影响的确切分子机制。
