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病理档案中石蜡块的可获取性和质量:共享病理信息网络(SPIN)的多机构研究

Availability and quality of paraffin blocks identified in pathology archives: a multi-institutional study by the Shared Pathology Informatics Network (SPIN).

作者信息

Patel Ashokkumar A, Gupta Dilipkumar, Seligson David, Hattab Eyas M, Balis Ulysses J, Ulbright Thomas M, Kohane Isaac S, Berman Jules J, Gilbertson John R, Dry Sarah, Schirripa Osvaldo, Yu Hong, Becich Michael J, Parwani Anil V

机构信息

Department of Pathology, Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh, Pittsburgh, PA, USA.

出版信息

BMC Cancer. 2007 Feb 28;7:37. doi: 10.1186/1471-2407-7-37.

Abstract

BACKGROUND

Shared Pathology Informatics Network (SPIN) is a tissue resource initiative that utilizes clinical reports of the vast amount of paraffin-embedded tissues routinely stored by medical centers. SPIN has an informatics component (sending tissue-related queries to multiple institutions via the internet) and a service component (providing histopathologically annotated tissue specimens for medical research). This paper examines if tissue blocks, identified by localized computer searches at participating institutions, can be retrieved in adequate quantity and quality to support medical researchers.

METHODS

Four centers evaluated pathology reports (1990-2005) for common and rare tumors to determine the percentage of cases where suitable tissue blocks with tumor were available. Each site generated a list of 100 common tumor cases (25 cases each of breast adenocarcinoma, colonic adenocarcinoma, lung squamous carcinoma, and prostate adenocarcinoma) and 100 rare tumor cases (25 cases each of adrenal cortical carcinoma, gastro-intestinal stromal tumor [GIST], adenoid cystic carcinoma, and mycosis fungoides) using a combination of Tumor Registry, laboratory information system (LIS) and/or SPIN-related tools. Pathologists identified the slides/blocks with tumor and noted first 3 slides with largest tumor and availability of the corresponding block.

RESULTS

Common tumors cases (n = 400), the institutional retrieval rates (all blocks) were 83% (A), 95% (B), 80% (C), and 98% (D). Retrieval rate (tumor blocks) from all centers for common tumors was 73% with mean largest tumor size of 1.49 cm; retrieval (tumor blocks) was highest-lung (84%) and lowest-prostate (54%). Rare tumors cases (n = 400), each institution's retrieval rates (all blocks) were 78% (A), 73% (B), 67% (C), and 84% (D). Retrieval rate (tumor blocks) from all centers for rare tumors was 66% with mean largest tumor size of 1.56 cm; retrieval (tumor blocks) was highest for GIST (72%) and lowest for adenoid cystic carcinoma (58%).

CONCLUSION

Assessment shows availability and quality of archival tissue blocks that are retrievable and associated electronic data that can be of value for researchers. This study serves to compliment the data from which uniform use of the SPIN query tools by all four centers will be measured to assure and highlight the usefulness of archival material for obtaining tumor tissues for research.

摘要

背景

共享病理信息学网络(SPIN)是一项组织资源计划,它利用医疗中心常规存储的大量石蜡包埋组织的临床报告。SPIN有一个信息学组件(通过互联网向多个机构发送与组织相关的查询)和一个服务组件(为医学研究提供经组织病理学注释的组织标本)。本文研究了通过参与机构的本地化计算机搜索识别出的组织块能否以足够的数量和质量被检索出来,以支持医学研究人员。

方法

四个中心评估了1990 - 2005年常见和罕见肿瘤的病理报告,以确定有合适肿瘤组织块的病例百分比。每个站点使用肿瘤登记、实验室信息系统(LIS)和/或与SPIN相关的工具,生成了一份包含100例常见肿瘤病例(乳腺腺癌、结肠腺癌、肺鳞状细胞癌和前列腺腺癌各25例)和100例罕见肿瘤病例(肾上腺皮质癌、胃肠道间质瘤[GIST]、腺样囊性癌和蕈样肉芽肿各25例)的列表。病理学家识别出带有肿瘤的玻片/组织块,并记录了肿瘤最大的前三张玻片以及相应组织块的可用性。

结果

对于常见肿瘤病例(n = 400),各机构的检索率(所有组织块)分别为83%(A)、95%(B)、80%(C)和98%(D)。所有中心对于常见肿瘤的肿瘤组织块检索率为73%,肿瘤平均最大尺寸为1.49厘米;检索率(肿瘤组织块)最高的是肺部(84%),最低的是前列腺(54%)。对于罕见肿瘤病例(n = 400),每个机构的检索率(所有组织块)分别为78%(A)、73%(B)、67%(C)和84%(D)。所有中心对于罕见肿瘤的肿瘤组织块检索率为66%,肿瘤平均最大尺寸为1.56厘米;检索率(肿瘤组织块)最高的是GIST(72%),最低的是腺样囊性癌(58%)。

结论

评估显示可检索的存档组织块的可用性和质量以及相关的电子数据对研究人员可能有价值。本研究有助于补充数据,通过这些数据将衡量四个中心对SPIN查询工具的统一使用情况,以确保并突出存档材料在获取肿瘤组织用于研究方面的有用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a30/1810540/778bbe8fd4f8/1471-2407-7-37-1.jpg

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