Vlahakis G
J Natl Cancer Inst. 1975 Nov;55(5):1217-8. doi: 10.1093/jnci/55.5.1217.
When low oncogenic milk-borne mammary tumor virus (MTV) of strain DD was tested in C3H-AvyfB mice, as compared with the similar strain C3HfB, mammary tumors occurred with a higher incidence and at lower age in C3H-AvyfBfDD (with DD-MTV) than in C3HfBfDD (with DD-MTV), as observed in virgin females. Since the effect of breeding tended to mask any difference between the breeders, mammary tumor incidences were similar with a slightly higher age at tumor occurrence in the C3H-AvyfBfDD females. Thus the C3H-AvyfB virgins (with the Avy gene) were almost as susceptible to mammary tumors with the less potent DD-MTV as were C3HfB virgins with the more virulent C3H-MTV of strain C3H.
当在C3H-AvyfB小鼠中测试低致癌性的DD株乳源性乳腺肿瘤病毒（MTV）时，与相似品系C3HfB相比，如在未交配的雌性小鼠中观察到的那样，C3H-AvyfBfDD（携带DD-MTV）比C3HfBfDD（携带DD-MTV）发生乳腺肿瘤的发病率更高且发病年龄更低。由于繁殖的影响往往会掩盖繁殖小鼠之间的任何差异，C3H-AvyfBfDD雌性小鼠乳腺肿瘤的发病率相似，但肿瘤发生的年龄略高。因此，带有Avy基因的C3H-AvyfB未交配小鼠对效力较低的DD-MTV诱发乳腺肿瘤的易感性几乎与带有毒性更强的C3H株C3H-MTV的C3HfB未交配小鼠一样。
