Imai S, Tsubura Y, Hilgers J, Michalides R
J Natl Cancer Inst. 1983 Sep;71(3):517-21.
The SHN mouse strain, which has a high incidence of mammary cancer, developed by inbreeding and selection from Swiss stock mice by Dr. H. Nagasawa and co-workers (Meiji University, Tokyo, Japan), harbored an endogenous mammary tumor virus (MTV) responsible for a high frequency of mammary tumors early in life. The locus was called "Mtv-4" and was only comparable with Mtv-2 of the GR mouse strain in its inducing capacity of mammary cancer. Molecular hybridization with 32P-labeled MTV complementary DNA showed that the characteristic Mtv-2 bands of the GR strain were absent in the SHN strain.
SHN小鼠品系由日本东京明治大学的长泽博士及其同事通过对瑞士种小鼠进行近亲繁殖和选育而成，其乳腺癌发病率很高，携带一种内源性乳腺肿瘤病毒（MTV），该病毒导致小鼠在生命早期乳腺肿瘤高发。该基因座被称为“Mtv-4”，在诱发乳腺癌的能力方面，仅与GR小鼠品系的Mtv-2相当。用32P标记的MTV互补DNA进行分子杂交显示，SHN品系中不存在GR品系特有的Mtv-2条带。
