Johnson Keegan S, Mills Monte D, Karp Karen A, Grunwald Juan E
Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Am J Ophthalmol. 2007 Apr;143(4):723-5. doi: 10.1016/j.ajo.2006.11.024. Epub 2006 Dec 20.
To determine the feasibility of using semiautomated analysis of digital fundus images to quantify the differences in retinal vascular diameter between retinopathy of prematurity (ROP) patients with and without plus disease.
Case-control study.
Thirty eyes of 15 patients with ROP were included in this study. Fourteen eyes of seven patients had plus disease and 16 eyes of eight patients had no evidence of plus disease. Digital fundus images were captured using an NM200D (Nidek, Inc, Aichi, Japan) camera. Vessel diameters were determined using VesselMap software (Imedos, Jena, Germany). The Student t test analysis was used to compare diameters of vessels with and without plus disease.
We found that the average venous diameter is significantly larger by 15% in the group with plus disease.
VesselMap analysis of digital images is feasible. This method is able to distinguish between veins with and without plus disease, and may be useful in telemedicine screening strategies.
确定使用数字眼底图像的半自动分析来量化有或无附加病变的早产儿视网膜病变（ROP）患者视网膜血管直径差异的可行性。
病例对照研究。
本研究纳入了15例ROP患者的30只眼。7例患者的14只眼有附加病变，8例患者的16只眼无附加病变证据。使用NM200D（日本爱知县尼德克公司）相机采集数字眼底图像。使用VesselMap软件（德国耶拿Imedos公司）测定血管直径。采用学生t检验分析比较有和无附加病变的血管直径。
我们发现有附加病变组的平均静脉直径显著大15%。
数字图像的VesselMap分析是可行的。该方法能够区分有和无附加病变的静脉，可能有助于远程医疗筛查策略。
