早产儿视网膜病变光凝治疗后视网膜血管直径缩小的定量分析。
Quantitative analysis of retinal vessel diameter reduction after photocoagulation treatment for retinopathy of prematurity.
作者信息
Johnson Keegan S, Mills Monte D, Karp Karen A, Grunwald Juan E
机构信息
Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
出版信息
Am J Ophthalmol. 2007 Jun;143(6):1030-2. doi: 10.1016/j.ajo.2007.01.058.
PURPOSE
To evaluate the feasibility of using semiautomated analysis of digital fundus images to quantify effects of photocoagulation on retinal vessel diameter in retinopathy of prematurity (ROP).
DESIGN
Case series.
METHODS
Fourteen eyes of seven patients with threshold ROP and 12 eyes of six controls were included. Fundus images were captured before and after photocoagulation, or one to three weeks apart in controls, using an NM200D camera (Nidek, Inc, Aichi, Japan). VesselMap software (Imedos, Jena, Germany) measured vessel diameter. The t test analysis was used to assess vessel changes.
RESULTS
The authors observed a significant reduction in average largest retinal vein diameter of -18% +/- 16% (+/-1 standard deviation). The average largest artery diameter trended down by -12% +/- 16%. Compared with controls, diameter reduction was significant in veins (P = .014) and arteries (P = .016).
CONCLUSIONS
The diameter of retinal vessels decreases after photocoagulation. VesselMap analysis of digital images is feasible and may be helpful in quantifying treatment effects.
目的
评估使用数字眼底图像的半自动分析来量化视网膜病变早产儿（ROP）光凝术后视网膜血管直径变化的可行性。
设计
病例系列。
方法
纳入7例阈值ROP患者的14只眼和6例对照者的12只眼。使用NM200D相机（日本爱知县尼德克公司）在光凝术前和术后，或对照者间隔1至3周拍摄眼底图像。VesselMap软件（德国耶拿Imedos公司）测量血管直径。采用t检验分析评估血管变化。
结果
作者观察到平均最大视网膜静脉直径显著降低-18%±16%（±1标准差）。平均最大动脉直径呈-12%±16%的下降趋势。与对照组相比，静脉（P = 0.014）和动脉（P = 0.016）的直径减小具有显著性。
结论
光凝术后视网膜血管直径减小。数字图像的VesselMap分析可行，可能有助于量化治疗效果。
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