Mladenov Mitko, Lubomirov Lubomir, Grisk Olaf, Avtanski Dimiter, Mitrokhin Vadim, Sazdova Iliyana, Keremidarska-Markova Milena, Danailova Yana, Nikolaev Georgi, Konakchieva Rossitza, Gagov Hristo
Faculty of Natural Sciences and Mathematics, Institute of Biology, "Ss. Cyril and Methodius" University, P.O. Box 162, 1000 Skopje, North Macedonia.
Institute of Physiology, Brandenburg Medical School Theodor Fontane, 16816 Neuruppin, Germany.
Antioxidants (Basel). 2023 May 19;12(5):1126. doi: 10.3390/antiox12051126.
This review is focused on the mechanisms that regulate health, disease and aging redox status, the signal pathways that counteract oxidative and reductive stress, the role of food components and additives with antioxidant properties (curcumin, polyphenols, vitamins, carotenoids, flavonoids, etc.), and the role of the hormones irisin and melatonin in the redox homeostasis of animal and human cells. The correlations between the deviation from optimal redox conditions and inflammation, allergic, aging and autoimmune responses are discussed. Special attention is given to the vascular system, kidney, liver and brain oxidative stress processes. The role of hydrogen peroxide as an intracellular and paracrine signal molecule is also reviewed. The cyanotoxins β--methylamino-l-alanine (BMAA), cylindrospermopsin, microcystins and nodularins are introduced as potentially dangerous food and environment pro-oxidants.
本综述聚焦于调节健康、疾病和衰老氧化还原状态的机制，对抗氧化应激和还原应激的信号通路，具有抗氧化特性的食品成分和添加剂（姜黄素、多酚、维生素、类胡萝卜素、黄酮类化合物等）的作用，以及鸢尾素和褪黑素在动物和人类细胞氧化还原稳态中的作用。讨论了偏离最佳氧化还原条件与炎症、过敏、衰老和自身免疫反应之间的相关性。特别关注血管系统、肾脏、肝脏和大脑的氧化应激过程。还综述了过氧化氢作为细胞内和旁分泌信号分子的作用。介绍了蓝藻毒素β-甲基氨基-L-丙氨酸（BMAA）、柱孢藻毒素、微囊藻毒素和节球藻毒素，它们是潜在危险的食品和环境促氧化剂。
