Ley Sebastian, Eichhorn Joachim, Ley-Zaporozhan Julia, Ulmer Herbert, Schenk Jens-Peter, Kauczor Hans-Ulrich, Arnold Raoul
Department of Radiology (E010), German Cancer Research Centre (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany.
Pediatr Radiol. 2007 May;37(5):426-36. doi: 10.1007/s00247-007-0414-4. Epub 2007 Mar 27.
Evaluation of the severity and the follow-up of aortic insufficiency (AI) are important tasks in paediatric cardiology. Assessment is based on clinical and echocardiographic (ECHO) findings such as the configuration of the valve and the regurgitation fraction (RF).
The goal of this study was to evaluate MRI compared to ECHO for determination of clinical severity, valve morphology and RF.
Thirty patients (age 3-27 years) with mild-to-severe AI were evaluated by clinical examination, ECHO (2-D and Doppler), and MRI at 1.5 T (2-D true-FISP cine short axis, phase-contrast flow in the ascending aorta).
Both methods identified 13 bicuspid and 17 tricuspid valves. Good correlations between ECHO and cine MRI were found for ventricular mass, stroke volume, and ejection fraction. A good linear correlation was found for the RF determined by ECHO and phase-contrast MRI (r = 0.7). The RF was 6% in mild AI, 17% in moderate AI, and 30% in severe AI. The different severity groups showed significantly different RF and it was possible to discriminate between clinical severity grades (P = 0.01).
ECHO and MRI showed good agreement in evaluating morphology and function of the left ventricle. The clinical severity of the disease can be evaluated correctly using MRI.
评估主动脉瓣关闭不全(AI)的严重程度及进行随访是小儿心脏病学中的重要任务。评估基于临床和超声心动图(ECHO)检查结果,如瓣膜形态和反流分数(RF)。
本研究的目的是对比ECHO和MRI在确定临床严重程度、瓣膜形态及RF方面的差异。
对30例年龄在3至27岁之间、患有轻至重度AI的患者进行了临床检查、ECHO(二维和多普勒)及1.5T MRI检查(二维真稳态进动快速成像电影短轴序列、升主动脉相位对比血流成像)。
两种方法均识别出13个二叶式瓣膜和17个三叶式瓣膜。ECHO与电影MRI在心室质量、每搏输出量及射血分数方面具有良好的相关性。ECHO测定的RF与相位对比MRI测定的RF具有良好的线性相关性(r = 0.7)。轻度AI患者的RF为6% ,中度AI患者为17% ,重度AI患者为30%。不同严重程度组的RF存在显著差异,且能够区分临床严重程度等级(P = 0.01)。
ECHO和MRI在评估左心室形态和功能方面显示出良好的一致性。使用MRI能够正确评估疾病的临床严重程度。