多瘤病毒相关核酸内切酶的起源。
Origin of the polyoma virus-associated endonuclease.
作者信息
McMillen J, Center M S, Consigli R A
出版信息
J Virol. 1975 Jan;17(1):127-31. doi: 10.1128/JVI.17.1.127-131.1976.
Abstract
Endonuclease activity can be found associated with highly purified preparations of polyoma virus. Evidence has been obtained that this enzyme is not an integral part of the virus but is contributed by the fetal calf serum used in maintenance of polyoma-infected cells. This finding is based on: (i) the lack of virion-associated endonuclease activity when virus is produced using serum-free media and (ii) the production of polyoma antibody which neutralizes fetal calf serum endonuclease activity.
摘要
在多瘤病毒的高度纯化制剂中可发现核酸内切酶活性。已有证据表明，这种酶并非病毒的组成部分，而是由用于维持多瘤病毒感染细胞的胎牛血清所提供。这一发现基于以下两点：（i）使用无血清培养基生产病毒时，病毒粒子不具有核酸内切酶活性；（ii）产生的多瘤病毒抗体可中和胎牛血清核酸内切酶活性。
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本文引用的文献
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