Michielutte R, Ernest J M, Moore M L, Meis P J, Sharp P C, Wells H B, Buescher P A
Department of Family and Community Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1084.
Prev Med. 1992 Jan;21(1):98-109. doi: 10.1016/0091-7435(92)90009-7.
Most epidemiological research dealing with the assessment of risk for low birthweight has focused on all low birthweight births. Studies that have attempted to distinguish between term and preterm low birthweights have tended to examine preterm low birthweight, since the risk of perinatal mortality and morbidity is greatest for this group of infants.
This study uses data from 25,408 singleton births in a 20-county region in North Carolina to identify and compare risk factors for term and preterm low birthweights, and also examines the usefulness of separate multivariate risk assessment systems for term and preterm low birthweights that could be used in the clinical setting.
Risk factors that overlap as significant predictors of both types of low birthweight include race, no previous live births, smoking, weight under 100 lb, and previous preterm or low birthweight birth. Age also is a significant predictor of both types of low birthweight, but in opposite directions. Younger age is associated with reduced risk of term low birthweight and increased risk of pattern low birthweight.
Comparison of all risk factors indicates that different multivariate models are needed to understand the epidemiology of preterm and term low birthweights. In terms of clinical value, a general risk assessment model that combines all low birthweight births is as effective as the separate models.
大多数关于低出生体重风险评估的流行病学研究都集中在所有低出生体重儿上。试图区分足月低体重儿和早产低体重儿的研究往往侧重于早产低体重儿,因为这组婴儿的围产期死亡率和发病率风险最高。
本研究使用北卡罗来纳州20个县地区25408例单胎分娩的数据,以识别和比较足月低体重儿和早产低体重儿的风险因素,并检验可用于临床环境的针对足月低体重儿和早产低体重儿的单独多变量风险评估系统的实用性。
作为两种类型低出生体重儿的重要预测因素而重叠的风险因素包括种族、既往无活产史、吸烟、体重低于100磅以及既往早产或低出生体重儿出生史。年龄也是两种类型低出生体重儿的重要预测因素,但方向相反。年龄较小与足月低体重儿风险降低和早产低体重儿风险增加相关。
对所有风险因素的比较表明,需要不同的多变量模型来理解早产低体重儿和足月低体重儿的流行病学。就临床价值而言,结合所有低出生体重儿的一般风险评估模型与单独的模型一样有效。