Bentzen J K
Ugeskr Laeger. 1992 Jan 13;154(3):126-9.
Xerostomia causes great inconvenience in patients treated with irradiation for cancer of the head and neck. For all practical purposes, salivary gland tissue becomes irreversibly incapable of functioning after doses of 40 Gy (standard fractioning). Curative doses are 60-70 Gy and, therefore, xerostomia can only be limited by attempting to involve as little as possible of salivary gland tissue in the irradiation fields. The limits of the tumour should be diagnosed as exactly as possible so that the irradiation fields are not made any larger than necessary "for safety". Therapeutic techniques which involve salivary gland tissue on only one side should be elected when this is justifiable. It is important to inform the patient about caries prohylaxis and the patient's own dentist should be involved in the problem as early as possible. Prophylatic fluorine treatment should be offered to alle of the patients.
口干给头颈部癌症放疗患者带来极大不便。实际上，给予40 Gy（标准分割剂量）后，唾液腺组织会不可逆地失去功能。根治性剂量为60 - 70 Gy，因此，只能通过尽量减少放疗野内唾液腺组织的照射来限制口干。应尽可能准确地诊断肿瘤边界，以使放疗野不会因“安全”因素而不必要地扩大。在合理的情况下，应选择仅累及一侧唾液腺组织的治疗技术。告知患者预防龋齿很重要，患者自己的牙医应尽早参与到这个问题中来。应为所有患者提供预防性氟治疗。
