Gitelman H J, Alderman F R, Perry S J
Division of Nephrology, University of North Carolina School of Medicine, Chapel Hill 27599-7155.
Am J Kidney Dis. 1992 Feb;19(2):140-3. doi: 10.1016/s0272-6386(12)70122-1.
Plasma silicon measurements have been obtained in patients with end-stage renal disease on chronic dialysis therapy. The mean +/- SE values for normal plasma silicon concentrations are .15 +/- .02 mg/L. All dialysis groups showed marked elevations in their plasma silicon that correlated with the silicon content of their respective dialysis fluids. The values of two different hemodialysis groups and a peritoneal dialysis group were 4.6 +/- .4, 2.5 +/- .2, and 1.9 +/- 1.2 mg/L, respectively. The silicon content of their respective dialysis fluids were 4.0 +/- .7, 0.5 +/- .4, and 0 +/- .1 mg/L. The ultrafiltrability of plasma silicon through Cuprophane membranes was 79 +/- 2%. Hemodialysis patients drinking high-silicon well water showed significantly higher plasma silicon levels than patients drinking lower silicon municipal water. It is concluded that use of dialysis fluid with elevated silicon levels and the consumption of water containing high concentrations of silicon are two important determinants of silicon levels in a dialysis population. We observed no overt effects of silicon accumulation on the health status of our dialysis patients.
对接受慢性透析治疗的终末期肾病患者进行了血浆硅含量测定。正常血浆硅浓度的均值±标准误为0.15±0.02mg/L。所有透析组的血浆硅含量均显著升高，且与各自透析液中的硅含量相关。两个不同血液透析组和一个腹膜透析组的血浆硅含量分别为4.6±0.4、2.5±0.2和1.9±1.2mg/L。各自透析液中的硅含量分别为4.0±0.7、0.5±0.4和0±0.1mg/L。血浆硅通过铜仿膜的超滤率为79±2%。饮用高硅井水的血液透析患者的血浆硅水平显著高于饮用低硅城市供水的患者。得出的结论是，使用硅含量升高的透析液以及饮用含高浓度硅的水是透析人群硅水平的两个重要决定因素。我们未观察到硅蓄积对透析患者健康状况有明显影响。
