Teuber S S, Saunders R L, Halpern G M, Brucker R F, Conte V, Goldman B D, Winger E E, Wood W G, Gershwin M E
Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, USA.
Biol Trace Elem Res. 1995 May;48(2):121-30. doi: 10.1007/BF02789186.
The metabolic fate of silicone gel leaked from an intact or ruptured prosthesis is unknown. In this study, serum was blindly assayed by inductively coupled plasma atomic emission spectroscopy (ICP-AES) for elemental silicon in 72 women with silicone gel breast implants and 55 control women (mean age 48 yr, both groups). Blood was drawn and processed using silicon-free materials. The mean silicon level in controls was 0.13 +/- 0.07 mg/L (range 0.06-0.35 mg/L), whereas in implant patients, the mean was significantly higher at 0.28 +/- 0.22 mg/L (range 0.06-0.87 mg/L) (P < 0.01, Student's t-test with correction for unequal variances). Using the mean of the control group + 2 SD as a cutoff for normal range (0.27 mg/L), 25/72 (34.7%) implant patients exceeded this value, compared with 2/55 (3.6%) controls. There was no significant correlation between past rupture of one or both implants, current rupture at the time of the blood draw, or the number of years with implants and silicon levels. The results suggest that serum silicon levels are elevated in many women with silicone gel breast implants. The chemical species involved and kinetics of this elevation remain to be determined.
从完整或破裂的假体中渗漏出的硅胶的代谢归宿尚不清楚。在本研究中，采用电感耦合等离子体原子发射光谱法（ICP-AES）对72例硅胶乳房植入物女性患者和55例对照女性（两组平均年龄均为48岁）的血清进行了元素硅的盲法检测。使用无硅材料采集和处理血液。对照组的平均硅水平为0.13±0.07mg/L（范围0.06 - 0.35mg/L），而植入物患者组的平均水平显著更高，为0.28±0.22mg/L（范围0.06 - 0.87mg/L）（P < 0.01，采用校正不等方差的学生t检验）。以对照组平均值 + 2标准差作为正常范围的临界值（0.27mg/L），72例植入物患者中有25例（34.7%）超过该值，而对照组55例中有2例（3.6%）超过该值。既往一侧或双侧植入物破裂、采血时的当前破裂情况或植入物使用年限与硅水平之间均无显著相关性。结果表明，许多硅胶乳房植入物女性患者的血清硅水平升高。升高所涉及的化学物质种类及其动力学仍有待确定。
