谷丙转氨酶升高和脂联素降低是2型糖尿病患者代谢综合征的特征。
Raised alanine transaminase and decreased adiponectin are features of the metabolic syndrome in patients with type 2 diabetes.
作者信息
Hickman Ingrid J, Whitehead Jonathan P, Prins Johannes B, Macdonald Graeme A
机构信息
Centre for Diabetes and Endocrine Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
出版信息
Diabetes Obes Metab. 2007 May;9(3):438-40. doi: 10.1111/j.1463-1326.2006.00604.x.
AIM
The aim of the study was to investigate the relationship between the metabolic syndrome (MS), adiponectin and abnormal liver enzymes in patients with type 2 diabetes.
METHODS
Fasting serum was collected from 189 patients with type 2 diabetes, adiponectin was measure using radioimmunoassay and features of the MS were assessed.
RESULTS
Mean ALT was significantly higher in patients with the MS and higher ALT was associated with lower adiponectin levels. As the number of features of MS increased, ALT increased and adiponectin decreased independent of glycaemic control.
CONCLUSION
Hypoadiponectinemia and the MS may be linked with liver injury in patients with type 2 diabetes.
目的
本研究旨在调查2型糖尿病患者中代谢综合征（MS）、脂联素与肝酶异常之间的关系。
方法
收集189例2型糖尿病患者的空腹血清，采用放射免疫分析法测定脂联素，并评估MS的特征。
结果
MS患者的平均谷丙转氨酶（ALT）显著更高，且较高的ALT与较低的脂联素水平相关。随着MS特征数量的增加，ALT升高而脂联素降低，且不受血糖控制的影响。
结论
低脂联素血症和MS可能与2型糖尿病患者的肝损伤有关。
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