RD, Department of Nutritional Science and Food Management, Ewha Womans University, 11-1 Daehyundong, Seodaemungu, Seoul, Korea.
J Am Coll Nutr. 2010 Jun;29(3):171-8. doi: 10.1080/07315724.2010.10719831.
To evaluate the relationship between serum adiponectin level, dietary intake, and metabolic syndrome (MetS) in type 2 diabetes mellitus (DM) patients, and to identify factors associated with serum adiponectin level.
A cross-sectional study was performed using 789 type 2 DM patients (406 men and 383 women) 40-80 years old. Subjects were classified into 3 groups on the basis of serum adiponectin level. General characteristics and anthropometric, hematologic, and dietary data were obtained for each subject.
The prevalence of hypoadiponectinemia (<4.0 µg/mL) was 57.4% in men and 32.4% in women. Serum adiponectin level was negatively correlated with body mass index (BMI), waist circumference, body fat percentage, and serum concentrations of insulin and triglyceride, and was positively correlated with high-density lipoprotein (HDL)-cholesterol level. Even though the direct association of nutrient intake with serum adiponectin concentration was not strong, various contributing factors for hypoadiponectinemia were strongly correlated with micronutrient intake, such as calcium, iron, and niacin. Both sexes in the group with the lowest adiponectin concentration had a higher prevalence of MetS and MetS components than corresponding sexes in the group with the highest adiponectin concentration.
Our findings show that hypoadiponectinemia is strongly associated with MetS in type 2 DM patients. Dietary intake may be indirectly associated with adiponectin levels through factors such as BMI, waist circumference, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride, HDL-cholesterol, and blood pressure. Therefore, our results suggest that manipulation of the level of adiponectin may prevent MetS and reduce the risk of cardiovascular disease in type 2 DM patients.
评估 2 型糖尿病患者血清脂联素水平、饮食摄入与代谢综合征（MetS）之间的关系，并确定与血清脂联素水平相关的因素。
本研究采用横断面研究，纳入 789 例年龄 40-80 岁的 2 型糖尿病患者（男 406 例，女 383 例），根据血清脂联素水平将患者分为 3 组。记录每位受试者的一般特征、人体测量学、血液学和饮食数据。
男性和女性中低脂联素血症（<4.0μg/mL）的患病率分别为 57.4%和 32.4%。血清脂联素水平与体质指数（BMI）、腰围、体脂百分比以及血清胰岛素和甘油三酯浓度呈负相关，与高密度脂蛋白（HDL）-胆固醇水平呈正相关。尽管营养素摄入与血清脂联素浓度的直接相关性不强，但导致低脂联素血症的各种因素与钙、铁和烟酸等微量营养素的摄入密切相关。脂联素浓度最低组中各性别发生 MetS 及其组分的比例均高于脂联素浓度最高组中相应性别的比例。
本研究结果表明，2 型糖尿病患者中低脂联素血症与 MetS 密切相关。饮食摄入可能通过 BMI、腰围、胰岛素、稳态模型评估的胰岛素抵抗（HOMA-IR）、甘油三酯、HDL-胆固醇和血压等因素间接与脂联素水平相关。因此，本研究结果提示，调节脂联素水平可能有助于预防 2 型糖尿病患者发生 MetS，并降低其发生心血管疾病的风险。
