细胞毒性T淋巴细胞（CTL）表位的噬菌体展示引发长期体内细胞毒性反应。
Phage display of a CTL epitope elicits a long-term in vivo cytotoxic response.
作者信息
Mascolo Dina, Barba Pasquale, De Berardinis Piergiuseppe, Di Rosa Francesca, Del Pozzo Giovanna
机构信息
Institute of Genetics and Biophysics Adriano Buzzati Traverso, CNR, Naples, Italy.
出版信息
FEMS Immunol Med Microbiol. 2007 Jun;50(1):59-66. doi: 10.1111/j.1574-695X.2007.00229.x. Epub 2007 Mar 28.
Abstract
The Ovalbumin(257-264) CTL epitope on the major coat protein of the filamentous bacteriophage in different antigen formulations was displayed and the immune response in C57BL6/J mice studied. The display of single cytotoxic epitope on the surface of the virion is sufficient to induce priming and sustain long-term major histocompatibility complex class I restricted cytotoxic T lymphocytes response in vivo. The filamentous bacteriophage is a versatile carrier able to display simultaneously either single or multiple epitopes and can elicit a cellular response carrying very little peptide (<1.5 microg).
摘要
展示了丝状噬菌体主要外壳蛋白上的卵清蛋白（257 - 264）细胞毒性T淋巴细胞（CTL）表位，并研究了其在不同抗原制剂中的情况以及在C57BL6/J小鼠中的免疫反应。病毒体表面单个细胞毒性表位的展示足以在体内引发致敏并维持长期的主要组织相容性复合体I类限制性细胞毒性T淋巴细胞反应。丝状噬菌体是一种通用载体，能够同时展示单个或多个表位，并且能够引发携带极少肽（<1.5微克）的细胞反应。
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