B'chir Fatma, Laouani Aicha, Ksibi Sonia, Arnaud Maurice J, Saguem Saâd
Metabolic Biophysics and Applied Pharmacology Laboratory, Department of Biophysics, Medicine Faculty of Sousse, 4002 Sousse, Tunisia.
Lung Cancer. 2007 Jul;57(1):26-33. doi: 10.1016/j.lungcan.2007.01.034. Epub 2007 Mar 27.
Increasing incidence of lung adenocarcinoma (Ad) is observed for the last two decades in all over the world and may become the most frequent lung cancer subtype in the next years. Its increasing prevalence has been well documented in United States for the last two decades. Geographical differences in the increase of Ad prevalence was also reported in Europe where the Squamous Cell Carcinoma (SCC) still predominates but the increase of Ad incidence was shown in the beginning of 1980s. In Tunisia, the incidence of Ad was relatively low in 1990 when compared to western countries and was shown to continue to increase with a more important rise of Ad incidence over SCC type. In this study the time-dependent increased incidence of Ad is reported between USA, Europe and Tunisia. A lag-time period of 10 years is observed between Tunisia and Europe for this increased incidence in smokers and about 20 years between USA and Tunisia. According to the literature, changes in the types of cigarettes smoked as well as modifications in time and geographical trends seem to explain partly the increased incidence of Ad lung cancer.
在过去二十年中，全球范围内肺腺癌（Ad）的发病率持续上升，未来几年它可能会成为最常见的肺癌亚型。在过去二十年里，美国肺腺癌患病率上升的情况已有充分记录。欧洲也报告了肺腺癌患病率上升的地理差异，在欧洲，鳞状细胞癌（SCC）仍占主导地位，但在20世纪80年代初就已显示出肺腺癌发病率的上升。在突尼斯，1990年时肺腺癌的发病率与西方国家相比相对较低，但后来显示出持续上升的趋势，且肺腺癌发病率的增长幅度超过了SCC类型。在本研究中，报告了美国、欧洲和突尼斯之间肺腺癌发病率随时间的增加情况。吸烟者中，突尼斯和欧洲之间这种发病率增加的滞后时间为10年，美国和突尼斯之间约为20年。根据文献，吸烟类型的变化以及时间和地理趋势的改变似乎部分解释了肺腺癌发病率的上升。
