Jia Manman, Li Jibin, Lin Hua, Zou Xiaonong, Zhao Ping
National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhongguo Fei Ai Za Zhi. 2017 Aug 20;20(8):516-521. doi: 10.3779/j.issn.1009-3419.2017.08.03.
Studies found that there were changes in histological subtypes of lung cancer patients in China. This study investigated the effect of smoking on lung cancer histology and its trend in Chinese male.
Demographic, smoking history and histological information about male lung cancer patients diagnosed or treated from 2000 to 2012 was collected from Cancer Hospital, Chinese Academy of Medical Science. Trends of histological subtypes calculated with annual percentage change (APC).
A total of 14,106 patients with lung cancer were enrolled, with smoking 11,750 cases and non-smoking 2,356 cases. The main histological type of smoking lung cancer was squamous cell carcinoma (SCC)(39.38%), followed by adenocarcinoma (ADC)(29.85%). Among smokers, the proportion of SCC decreased from 44.19% to 35.50% (APC=-1.9%, P<0.001), however, the ADC increased from 15.25% to 41.85% (APC=6.8%, P<0.001). Adenosquamous carcinoma (ASC) was from 4.13% to 0.72% (APC=-14.9%, P<0.001). In non-smokers, the ADC was 53.86%, and SCC was 16.64%. ADC increased from 38.03% to 67.83% (APC=4.3%, P<0.001). Distributions of LCC and ASC were scattered.
CONCLUSIONS: Proportion of ADC increased significantly in smoking and non-smoking lung cancer patients, and the relationship between non-smoking factor exposure and lung cancer should be further studied. .
研究发现中国肺癌患者的组织学亚型存在变化。本研究调查了吸烟对中国男性肺癌组织学的影响及其变化趋势。
收集了2000年至2012年在中国医学科学院肿瘤医院诊断或治疗的男性肺癌患者的人口统计学、吸烟史和组织学信息。用年度百分比变化（APC）计算组织学亚型的变化趋势。
共纳入14106例肺癌患者，其中吸烟患者11750例，非吸烟患者2356例。吸烟肺癌的主要组织学类型是鳞状细胞癌（SCC）（39.38%），其次是腺癌（ADC）（29.85%）。在吸烟者中，SCC的比例从44.19%降至35.50%（APC=-1.9%，P<0.001），然而，ADC从15.25%升至41.85%（APC=6.8%，P<0.001）。腺鳞癌（ASC）从4.13%降至0.72%（APC=-14.9%，P<0.001）。在非吸烟者中，ADC为53.86%，SCC为16.64%。ADC从38.03%升至67.83%（APC=4.3%，P<0.001）。大细胞癌（LCC）和ASC的分布较为分散。
吸烟和非吸烟肺癌患者中腺癌的比例均显著增加，应进一步研究非吸烟因素暴露与肺癌之间的关系。
