Stereospecific construction of substituted piperidines. Synthesis of (-)-paroxetine and (+)-laccarin.
作者信息
Bower John F, Riis-Johannessen Thomas, Szeto Peter, Whitehead Andrew J, Gallagher Timothy
机构信息
School of Chemistry, University of Bristol, Bristol, UKBS8 1TS.
出版信息
Chem Commun (Camb). 2007 Feb 21(7):728-30. doi: 10.1039/b617260a. Epub 2007 Jan 18.
DOI:10.1039/b617260a
PMID:17392964
Abstract
Short and efficient enantioselective syntheses of (-)-paroxetine and (+)-laccarin are described based on the highly stereospecific cleavage of C(3)-substituted 1,3-cyclic sulfamidates.
摘要
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