白纹伊蚊浓核病毒与其他细小病毒的结构比较。

Structure comparisons of Aedes albopictus densovirus with other parvoviruses.

作者信息

Cheng LingPeng, Chen SenXiong, Zhou Z H, Zhang JingQiang

机构信息

Department of Biomedical Engineering, School of Bioscience & Bioengineering, South China University of Technology, Guangzhou, 510640, China.

出版信息

Sci China C Life Sci. 2007 Feb;50(1):70-4. doi: 10.1007/s11427-007-2036-3.

DOI:10.1007/s11427-007-2036-3

PMID:17393085

Abstract

Parvoviridae is a family of the smallest viruses known with a wide variety of hosts. The capsid structure of the Aedes albopictus C6/36 cell densovirus (C6/36 DNV) at 1.2-nm resolution was obtained by electron cryomicroscopy (cryoEM) and three-dimensional (3D) image reconstruction. Structure comparisons between the C6/36 DNV and other parvoviruses reveal that the degree of structural similarity between C6/36 DNV and the human parvovirus B19 is higher than that between C6/36 DNV and other insect parvoviruses. The amino acid sequence comparisons of structural and non-structural proteins also reveal higher levels of similarity between C6/36 DNV and parvovirus B19 than those between C6/36 DNV and other parvoviruses. These findings indicate that C6/36 DNV is closely related to the human virus B19, and the former might evolve from the human species other than from other insect viruses.

摘要

细小病毒科是已知的最小病毒家族，宿主种类繁多。通过电子冷冻显微镜（cryoEM）和三维（3D）图像重建，获得了白纹伊蚊C6/36细胞浓核病毒（C6/36 DNV）在1.2纳米分辨率下的衣壳结构。C6/36 DNV与其他细小病毒的结构比较表明，C6/36 DNV与人类细小病毒B19之间的结构相似程度高于C6/36 DNV与其他昆虫细小病毒之间的相似程度。结构蛋白和非结构蛋白的氨基酸序列比较也表明，C6/36 DNV与细小病毒B19之间的相似性水平高于C6/36 DNV与其他细小病毒之间的相似性水平。这些发现表明，C6/36 DNV与人类病毒B19密切相关，前者可能从人类物种而非其他昆虫病毒进化而来。