一种来自粗壮美登木的具有抗伤害感受活性的新三萜。

A new triterpene with antinociceptive activity from Maytenus robusta.

作者信息

Niero Rivaldo, Mafra Ana P, Lenzi Ana C, Cechinel-Filho Valdir, Tischer Cesar A, Malheiros Angela, De Souza Marcia M, Yunes Rosendo A, Delle Monache Franco

机构信息

Núcleo de Investigações Quimico-Farmacêuticas (NIQFAR)/CCS, Universidade do Vale do Itajaí (UNIVALI), 88.302-202 Itajaí, SC, Brazil.

出版信息

Nat Prod Res. 2006 Dec;20(14):1315-20. doi: 10.1080/14786410601101951.

DOI:10.1080/14786410601101951

PMID:17393657

Abstract

A new triterpene 3,15-dioxo-21alpha-hydroxy friedelane has been isolated from methanol extract of Maytenus robusta and its structure elucidated on the basis of spectral analysis. Stigmasterol, friedelin, friedelanol and 3,15-dioxo friedelane were also obtained. 3,15-dioxo-21alpha-hydroxy friedelane was analyzed against the writhing test in mice and exhibited potent dose-dependent effects with an ID50 value of 12.5 +/- 2.1 micromol kg(-1) and a maximal inhibition of 85.90%. It was about 10-fold more active than aspirin and paracetamol, used as reference drugs.

摘要

从粗壮美登木的甲醇提取物中分离出一种新的三萜类化合物3,15-二氧代-21α-羟基木栓烷，并通过光谱分析确定了其结构。还得到了豆甾醇、木栓酮、木栓醇和3,15-二氧代木栓烷。对3,15-二氧代-21α-羟基木栓烷进行了小鼠扭体试验分析，结果显示其具有显著的剂量依赖性效应，ID50值为12.5±2.1微摩尔/千克，最大抑制率为85.90%。它的活性约为用作参考药物的阿司匹林和对乙酰氨基酚的10倍。