软组织肉瘤中III型胶原蛋白的代谢
Type III collagen metabolism in soft tissue sarcomas.
作者信息
Wiklund T A, Elomaa I, Blomqvist C P, Risteli L, Risteli J
机构信息
Department of Radiotherapy and Oncology, Helsinki University Central Hospital, Finland.
出版信息
Br J Cancer. 1992 Feb;65(2):193-6. doi: 10.1038/bjc.1992.40.
Sera of 85 patients with benign soft tissue lesions or sarcomas of soft tissues were investigated for a collagen metabolite, the aminoterminal propeptide of type III procollagen (PIIINP). Patients were divided into three groups: benign soft tissue lesions (n = 39), localised (n = 29) and metastatic (n = 18) soft tissue sarcomas (STS). Values of PIIINP above the reference range were found in 15%, 28% and 50% of the respective groups. The difference in the concentration of PIIINP was statistically significant between the benign lesions and the localised sarcomas; P = 0.05, and between the benign lesions and the metastatic sarcomas; P less than 0.001. In localised sarcomas there was a correlation between PIIINP and bone-involvement (r = 0.61, P = 0.002) and in metastatic disease between PIIINP and liver metastases (r = 0.77, P less than 0.001). In localised sarcomas the overall survival for patients with a value of PIIINP above the reference range was significantly poorer (P = 0.03) than for patients with values within the reference range, even after stratification for the histological malignancy grade of the tumours (P = 0.04).
对85例患有良性软组织病变或软组织肉瘤的患者血清进行了III型前胶原氨基端前肽（PIIINP）这种胶原代谢产物的检测。患者被分为三组：良性软组织病变组（n = 39）、局限性软组织肉瘤组（n = 29）和转移性软组织肉瘤组（n = 18）。上述各组中PIIINP值高于参考范围的比例分别为15%、28%和50%。良性病变与局限性肉瘤之间以及良性病变与转移性肉瘤之间PIIINP浓度差异具有统计学意义；前者P = 0.05，后者P < 0.001。在局限性肉瘤中，PIIINP与骨受累之间存在相关性（r = 0.61，P = 0.002），在转移性疾病中，PIIINP与肝转移之间存在相关性（r = 0.77，P < 0.001）。在局限性肉瘤中，即使对肿瘤的组织学恶性程度进行分层后，PIIINP值高于参考范围的患者总生存期仍显著低于（P = 0.03）参考范围内的患者（P = 0.04）。
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