Wiklund T, Blomqvist C, Risteli L, Risteli J, Karaharju E, Elomaa I
Department of Radiotherapy and Oncology, University of Helsinki, Finland.
Br J Cancer. 1996 Jan;73(1):106-9. doi: 10.1038/bjc.1996.19.
Three biochemical markers of collagen metabolism were measured in 39 osteosarcoma patients. The pretreatment values did not predict outcome, and the markers showed no consistent change upon development of metastases. Both the age of the patients and the multimodality therapy affected the collagen metabolites. These findings emphasise the need for cautious interpretation of tumour-associated markers.
在39例骨肉瘤患者中测量了三种胶原代谢的生化标志物。治疗前的值不能预测预后，并且这些标志物在发生转移时没有表现出一致的变化。患者的年龄和多模式治疗都影响了胶原代谢产物。这些发现强调了对肿瘤相关标志物进行谨慎解读的必要性。
