Hørslev-Petersen K, Bentsen K D, Junker P, Mathiesen F K, Hansen T M, Lorenzen I
Department of Medicine, University of Copenhagen, Hvidovre Hospital, Denmark.
Clin Rheumatol. 1988 Mar;7(1):61-8. doi: 10.1007/BF02284058.
Measurement of the aminoterminal type III procollagen peptide in serum has been suggested as a marker of the biosynthesis of collagen type III, a major connective tissue component in repair processes. In the present study the propeptide level correlated with the inflammatory synovial mass in rheumatoid arthritis and osteoarthritis. This implies that the propeptide level reflects the collagen type III synthesis occurring in the synovial repair processes, whether they were caused by inflammatory or degenerative rheumatic disorders. Physical activity did not enhance the transition of the propeptide from the synovial fluid or the inflamed synovial membrane to the blood. Normal serum propeptide values were observed in most patients with ankylosing spondylitis and degenerative diseases of the spine. This may reflect the lower amount of inflammatory tissue in these diseases and hence the sensitivity of the assays.
血清中Ⅲ型前胶原氨基端肽的测定已被提议作为Ⅲ型胶原生物合成的标志物，Ⅲ型胶原是修复过程中的一种主要结缔组织成分。在本研究中，该前肽水平与类风湿关节炎和骨关节炎的炎性滑膜肿块相关。这意味着前肽水平反映了滑膜修复过程中发生的Ⅲ型胶原合成，无论这些过程是由炎性还是退行性风湿性疾病引起的。体力活动并未增强前肽从滑液或炎性滑膜向血液的转移。在大多数强直性脊柱炎和脊柱退行性疾病患者中观察到血清前肽值正常。这可能反映了这些疾病中炎性组织量较低，从而体现了检测方法的敏感性。
