神经元特异性烯醇化酶——精原细胞瘤的一种血清肿瘤标志物？
Neuron-specific enolase--a serum tumour marker in seminoma?
作者信息
Fosså S D, Klepp O, Paus E
机构信息
Department of Medical Oncology, Norwegian Radium Hospital, Oslo.
出版信息
Br J Cancer. 1992 Feb;65(2):297-9. doi: 10.1038/bjc.1992.59.
The clinical significance of neuron-specific enolase (NSE) as a tumour marker was evaluated in 54 patients with seminoma. Before orchiectomy NSE was elevated in six out of 21 patients with stage I seminoma and 11 out of 16 patients with metastases. After orchiectomy NSE normalised in all evaluated stage I cases, but was still elevated in six out of 12 patients with metastatic disease. NSE monitored the effect of cisplatin-based chemotherapy in patients with metastases. In some patients, increased serum NSE was found together with raised levels of human choriogonadotropin (HCG) and lactate dehydrogenase (LDH), while in others only NSE was elevated. No false positive NSE values were observed. NSE seems to be a clinically worthwhile serum tumour marker for monitoring seminoma patients, with a sensitivity and specificity of the same order as HCG.
对54例精原细胞瘤患者评估了神经元特异性烯醇化酶（NSE）作为肿瘤标志物的临床意义。在睾丸切除术前，21例Ⅰ期精原细胞瘤患者中有6例NSE升高，16例有转移的患者中有11例NSE升高。睾丸切除术后，所有评估的Ⅰ期病例NSE均恢复正常，但12例有转移疾病的患者中有6例NSE仍升高。NSE监测了转移性疾病患者基于顺铂化疗的效果。在一些患者中，血清NSE升高同时伴有人绒毛膜促性腺激素（HCG）和乳酸脱氢酶（LDH）水平升高，而在另一些患者中仅NSE升高。未观察到NSE假阳性值。NSE似乎是监测精原细胞瘤患者的一种具有临床价值的血清肿瘤标志物，其敏感性和特异性与HCG相当。
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