Zhao Jian, Yue Dawei, Campo Marino A, Larock Richard C
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
J Am Chem Soc. 2007 Apr 25;129(16):5288-95. doi: 10.1021/ja070657l. Epub 2007 Mar 31.
Biologically interesting fluoren-9-one and xanthen-9-one derivatives have been prepared by a novel aryl to imidoyl palladium migration, followed by intramolecular arylation. The fluoren-9-one synthesis appears to involve both a palladium migration mechanism and a C-H activation process proceeding through an unprecedented organopalladium(IV) hydride intermediate. The results from deuterium labeling experiments are consistent with the proposed dual mechanism.
