Chetty R, Close P M, Timme A H, Willcox P A, Forder M D
Department of Anatomical Pathology, University of Cape Town, South Africa.
Cancer. 1992 Mar 1;69(5):1124-9. doi: 10.1002/cncr.2820690511.
A primary mucosa-associated lymphoid tissue lymphoma of the lung in a 27-year-old man was found. The tumor was composed mainly of centrocyte-like cells and plasma cells. These two components were demarcated sharply from each other, resulting in a zoning or biphasic pattern. This characteristic pattern also was present in the involved regional lymph nodes. Monoclonality of tumor cells was shown immunohistochemically and by in situ hybridization techniques. This article also highlights the use of in situ hybridization in detecting light chain mRNA in paraffin sections.
发现一名27岁男性患有原发性肺黏膜相关淋巴组织淋巴瘤。肿瘤主要由中心细胞样细胞和浆细胞组成。这两种成分彼此界限分明，形成了分区或双相模式。这种特征性模式在受累的区域淋巴结中也存在。通过免疫组织化学和原位杂交技术显示肿瘤细胞具有单克隆性。本文还强调了原位杂交在石蜡切片中检测轻链mRNA的应用。
