Chen Chih-Mei, Rzehak Peter, Zutavern Anne, Fahlbusch Bärbel, Bischof Wolfgang, Herbarth Olf, Borte Michael, Lehmann Irina, Behrendt Heidrun, Krämer Ursula, Wichmann H-Erich, Heinrich Joachim
GSF-National Research Centre for Environment and Health, Institute of Epidemiology, Neuherberg, Germany.
J Allergy Clin Immunol. 2007 May;119(5):1148-55. doi: 10.1016/j.jaci.2007.02.017. Epub 2007 Apr 2.
The influence of cat allergen exposure in early childhood on the development of sensitization and allergic diseases is complex. Little is known about the natural course of the sensitization development within individuals.
We investigated the association between cat allergen exposure in infancy and cat ownership and cat contact during childhood and the development of cat sensitization and allergic diseases up to age 6 years using a longitudinal analysis approach.
Overall, 2166 children from an ongoing birth cohort study were included in the analysis. House dust samples were collected 3 months after birth. Cat allergen levels were extracted. Blood samples were collected when the children were 2 and 6 years old. Information on the allergic symptoms of children and doctor-diagnosed allergic disease were collected at each follow-up using questionnaires.
Cat allergen exposure in infancy was positively associated with sensitization at age 2 years but not at age 6 years. No associations existed between cat allergen exposure in infancy and allergic symptoms and diseases up to age 6 years. Cumulative allergen exposure from cat ownership and regular cat contact increased the risk of cat sensitization up to age 6 years.
Cat allergen exposure in infancy increases the risk of sensitization development in early childhood but not in school-age children. Cumulative allergen exposure from cat ownership and regular cat contact during childhood contribute to sensitization development up to school age.
Cat allergen avoidance at home alone might be not effective to prevent the development of allergic sensitization in young children.
儿童早期接触猫过敏原对致敏和过敏性疾病发展的影响较为复杂。个体内部致敏发展的自然过程鲜为人知。
我们采用纵向分析方法，研究婴儿期接触猫过敏原以及儿童期养猫和接触猫与6岁前猫致敏和过敏性疾病发展之间的关联。
总体而言，一项正在进行的出生队列研究中的2166名儿童纳入了分析。出生后3个月收集家庭灰尘样本，提取猫过敏原水平。儿童在两岁和六岁时采集血样。每次随访时使用问卷收集儿童过敏症状和医生诊断的过敏性疾病信息。
婴儿期接触猫过敏原与2岁时的致敏呈正相关，但与6岁时的致敏无关。婴儿期接触猫过敏原与6岁前的过敏症状和疾病之间不存在关联。养猫和经常接触猫导致的累积过敏原暴露增加了6岁前猫致敏的风险。
婴儿期接触猫过敏原会增加幼儿期致敏发展的风险，但不会增加学龄儿童的致敏风险。儿童期养猫和经常接触猫导致的累积过敏原暴露会导致学龄期致敏发展。
仅在家中避免接触猫过敏原可能无法有效预防幼儿过敏性致敏的发展。
