Göhl H, Buck R, Strathmann H
Gambro Dialysatoren KG, Hechingen, BRD.
Contrib Nephrol. 1992;96:1-25. doi: 10.1159/000421119.
Progress in membrane and membrane process development have contributed to the continuous improvement of the extracorporeal treatment of renal failure during the last 40 years. Today membranes can be adapted to the specific needs required by their clinical application. Synthetic structures like the polyamide membranes offer a wide range of possibilities in performance and hemocompatibility, due to: (1) the use of block polymers or polymer blends and mixtures, and (2) modification of membrane structure, pore size and porosity, due to changes of the preparation process. However, further improvements are still required to achieve the ultimate goal of matching the performance of biological membranes.
在过去40年里,膜及膜工艺的发展推动了肾衰竭体外治疗的持续进步。如今,膜能够根据其临床应用的特定需求进行调整。诸如聚酰胺膜之类的合成结构在性能和血液相容性方面提供了广泛的可能性,这归因于:(1)嵌段聚合物或聚合物共混物及混合物的使用;(2)由于制备工艺的改变而对膜结构、孔径和孔隙率进行的改性。然而,要实现与生物膜性能相匹配的最终目标,仍需要进一步改进。