聚丙稀腈和聚酰胺血液滤过器对庆大霉素和奈替米星的体外吸附。
In vitro adsorption of gentamicin and netilmicin by polyacrylonitrile and polyamide hemofiltration filters.
机构信息
Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T., Hong Kong.
出版信息
Antimicrob Agents Chemother. 2010 Feb;54(2):963-5. doi: 10.1128/AAC.01215-09. Epub 2009 Nov 30.
Abstract
Adsorption of gentamicin and netilmicin by new polyacrylonitrile and polyamide hemofiltration filters was studied over 4 h, using a single-compartment in vitro continuous venovenous hemofiltration model. After the first dose (16.6 mg of gentamicin, 19.3 mg of netilmicin), 14.9 mg of gentamicin and 19.2 mg of netilmicin were adsorbed to polyacrylonitrile filters in vitro. Adsorption by polyacrylonitrile filters was rapid and irreversible and could be increased by repeated dosing. Adsorption by polyamide filters was substantially less.
摘要
研究了新的丙烯腈和聚酰胺血液滤过过滤器在 4 小时内对庆大霉素和奈替米星的吸附作用，使用单室体外连续静脉-静脉血液滤过模型。首剂量（16.6mg 庆大霉素，19.3mg 奈替米星）后，14.9mg 庆大霉素和 19.2mg 奈替米星被体外吸附到丙烯腈过滤器上。丙烯腈过滤器的吸附作用迅速且不可逆，可通过重复给药增加。聚酰胺过滤器的吸附作用则显著较低。
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