Kalra Bhupinder Singh, Aggarwal Sarita, Khurana Nita, Gupta Usha
Department of Pharmacology, Maulana Azad Medical College, New Delhi 110 002, India.
Indian J Gastroenterol. 2007 Jan-Feb;26(1):18-21.
To evaluate the hepatoprotective potential of cimetidine in hepatotoxicity induced by isoniazid-rifampicin combination in albino rabbits.
Six groups of six rabbits each were studied. Three groups received saline (control), isoniazid (50 mg/Kg/d) alone or isoniazid with rifampicin (100 mg/Kg/d) daily orally for 7 days. Other groups received intraperitoneal cimetidine (50 mg/Kg/d) alone or cimetidine (50 or 120 mg/Kg/d) along with isoniazid-rifampicin combination. Serum levels of liver enzymes were measured at baseline and on day 8 and liver histology was studied on day 8.
Rabbits receiving isoniazid alone for 7 days showed no increase in serum ALT and AST levels, whereas those receiving isoniazid-rifampicin combination had a 3-4-fold increase in these levels (p=0.02). Animals receiving cimetidine pre-treatment did not show a significant increase in ALT and AST levels. Histological changes in the liver were more common with isoniazid-rifampicin combination than with isoniazid only. These changes were reduced in animals receiving low-dose cimetidine and prevented in those receiving high-dose cimetidine.
Cimetidine in high dose can prevent hepatotoxicity induced by isoniazid-rifampicin combination.
评估西咪替丁对白化兔异烟肼-利福平联合用药所致肝毒性的肝保护潜力。
对六组兔子进行研究，每组六只。三组分别接受生理盐水（对照组）、单独使用异烟肼（50毫克/千克/天）或异烟肼与利福平联合用药（100毫克/千克/天），每日口服，持续7天。其他组分别单独接受腹腔注射西咪替丁（50毫克/千克/天）或西咪替丁（50或120毫克/千克/天）与异烟肼-利福平联合用药。在基线和第8天测量血清肝酶水平，并在第8天研究肝脏组织学。
单独接受异烟肼治疗7天的兔子血清谷丙转氨酶（ALT）和谷草转氨酶（AST）水平没有升高，而接受异烟肼-利福平联合用药的兔子这些水平升高了3至4倍（p=0.02）。接受西咪替丁预处理的动物ALT和AST水平没有显著升高。异烟肼-利福平联合用药组肝脏的组织学变化比单独使用异烟肼组更常见。在接受低剂量西咪替丁的动物中这些变化减少，在接受高剂量西咪替丁的动物中这些变化得到预防。
高剂量西咪替丁可预防异烟肼-利福平联合用药所致的肝毒性。
